Saniculamin C, a new flavonoid from Sanicula lamelligera

Abstract

A new flavonoid named saniculamin C (1), together with six known compounds (2-7), were isolated from the whole plants of Sanicula lamelligera Hance. The chemical structures were elucidated by spectroscopic and physico-chemical analyses. All isolates were evaluated for in vitro cytotoxic activities against four human cancer cell lines, HepG2, SGC-7901 gastric cancer, Hela and A-549 lung cancer. Compound 1 showed potent antiproliferative activities against SGC-7901 cells with IC₅₀ value of 7.45 μM. In addition, compound 6 exhibited weak antiproliferative activities against HepG2, SGC-7901, Hela cancer cells with IC₅₀ values of 10.43, 8.24 and 15.32 μM, respectively.

Graphical Abstract

Keywords:

• Sanicula lamelligera
• Apiaceae
• flavonoid
• cytotoxicity

Acknowledgments

We thank Dr Dan Cai and Dr Xin Li in the Research Center for Chemistry, Sichuan University, and the workers of Kunming Plant Biotechnology Co. LTD.

Disclosure statement

No potential conflict of interest was reported by the authors.