https://orcid.org/0000-0003-2797-4625
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Abstract
Two new chlorophenolic glucosides curculigines P (1) and Q (2), together with seven known compounds (3–9), were isolated from the dried rhizomes of Curculigo orchioides. Their structures were determined by spectroscopic methods including 1 D, 2 D NMR and MS. All the isolated compounds were evaluated on 5α-reductase activity by a HaCaT-based bioassay. Compounds 1–9 showed varying degrees of inhibiting activity against 5α-reductase, while compound 1 indicated the most potent inhibitory effect.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
This study was financially supported by Shanghai “Three-year Action Plan” Fund (Grant number: ZY (2018-2020)-CCCX-5002), Shanghai Natural Science Fund (Grant number: 19ZR1457200), and “Xinglin Talent” Program from Shanghai University of Traditional Chinese Medicine (Grant number: 2017).