Hyperacmosins H-J, three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum acmosepalum

Abstract

Three new polycyclic polyprenylated acylphloroglucinol derivatives, hyperacmosins H-J (1–3), with four known compounds (4–7), were isolated from the air-dried aerial parts of Hypericum acmosepalum. Especially, compounds 1 and 2 were identified as methylated polycyclic polyprenylated acylphloroglucinol derivatives (mPPAPs). Their structures were established by NMR, HRESIMS and experimental electronic circular dichroism (ECD) spectra. The hepatoprotective activity of seven compounds were evaluated. Compounds 1 and 5 exhibited hepatoprotective activity against paracetamol-induced HepG2 cell damage.

Keywords:

• Hypericum acmosepalum
• methylated polycyclic polyprenylated acylphloroglucinols (mPPAPs)
• hepatoprotective

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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by Projects of International Cooperation and Exchanges NSFC [grant number NSFC-VR 81361138020]; The Drug Innovation Major Project [grant number 2018ZX09711001-001-001]; the CAMS Innovation Fund for Medical Sciences (CIFMS); and the CAMS Initiative for Innovative Medicine [grant number CAMS-I2M 2016-I2M-1-010].