225
Views
4
CrossRef citations to date
0
Altmetric
Note

1,10-seco guaianolide-type sesquiterpenoids from Chrysanthemum indicum

, , , , , , , & show all
Pages 877-883 | Received 29 Apr 2020, Accepted 22 Jun 2020, Published online: 30 Jun 2020
 

ABSTACT

A chemical investigation of the whole plant of traditional Chinese medicine, Chrysanthemum indicum L., led to the discovery of six guaianolide-type sesquiterpenoids 1–6 with a 1,10-splited skeleton. The structure of the new compound 1 was established by extensive analysis of UV, IR, MS, NMR and ECD data. Compounds 3–6 are mutually stereoisomers with four chiral centers and their absolute configurations were determined by comparison of ECD spectra. The anti-inflammatory effects of these isolates on lipopolysaccharide (LPS)-induced nitric oxide (NO) were investigated in RAW 264.7 cells. Results showed that most of the compounds displayed NO production inhibitory activities with IC50 values ranged from 3.54 to 8.17 μM.

Graphical abstract

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The financial support from the Central Government Guide Local Science and Technology Development Funds (No.14104349), the National Natural Science Foundation of China (No.31300284), and Scientific and Technological Key Project in Henan Province (No.192102310438).

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.