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Abstract
Two new benzoic acid derivatives, sophophenoside A (1) and sophophenoside B (2), were isolated from Sophora flavescens. Their structures were elucidated by detailed spectroscopic analysis and chemical methods. Compounds 1 and 2 were assayed for their hepatoprotective activity on the cytotoxic effect of D-galactosamine on HL-7702 cells, and compound 1 exhibited a moderate hepatoprotective activity at a concentration of 10 μM.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the authors.
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Funding
This work was financially supported by the National Natural Science Foundation of China (No. 81973194); the CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-1-010); and State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medcial University (FAMP201706K).