Two new sesquiterpene aryl esters from Armillaria gallica 012m

Abstract

Two new sesquiterpene aryl esters, armimelleolides A and B (1 and 2), and four known ones, were isolated from the EtOAc extract of Armillaria gallica 012 m by column chromatography on silica gel, reversed-phase C₁₈ silica gel and semi-preparative HPLC. Their structures were elucidated on the basis of spectroscopic methods, including extensive 1 D NMR, 2 D NMR and MS. All these compounds showed potential antitumor activities against at least one of the human cancer cell lines (A549, HCT-116, M231 and W256), with IC₅₀ ranging from 2.57 to 19.94 μM.

Graphical abstract

KEYWORDS:

• Tricholomataceae
• Armillaria gallica 012m
• sesquiterpene aryl ester
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

This project was in part supported financially by the National Natural Science Foundation of China (Nos.31760096, 31960095, 81660717, and 81960777), Yunnan Ten-thousand Talents Program to W.-G.W., the National Natural Science Foundation of Yunnan Provinces (No. 2019FB027). Yunnan Provincial Science and Technology Department–– Applied Basic Research Joint Special Funds of Yunnan University of Traditional Chinese Medicine [grant number 2019FF002(-005), 2018FF001(-029)].