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Journal of Asian Natural Products Research Volume 24, 2022 - Issue 3
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Articles

Palitantin derivatives from the Antarctic fungus Geomyces sp. 3-1

Hao-Bing Yua Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Second Military Medical University, Shanghai200433, China;b College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai200433, ChinaORCID Iconhttps://orcid.org/0000-0003-0516-4664View further author information
ORCID Icon,
Bo Hua Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Second Military Medical University, Shanghai200433, ChinaView further author information
,
Jie Kongb College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai200433, ChinaView further author information
,
Yun-Hai Lib College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai200433, ChinaView further author information
,
Ying Hea Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Second Military Medical University, Shanghai200433, ChinaView further author information
,
Xiao-Ling Lub College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai200433, ChinaView further author information
,
Bing-Hua Jiaob College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai200433, ChinaView further author information
&
Xiao-Yu Liua Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Second Military Medical University, Shanghai200433, ChinaCorrespondence[email protected]
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Pages 252-258 | Received 14 Dec 2020, Accepted 07 Apr 2021, Published online: 23 Apr 2021
 
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Abstract

Two new polyketides, palitantins B and C (1 and 2), along with one known related compound (+)-palitantin (3) were obtained from the culture of the Antarctic fungus Geomyces sp. 3-1. The structures of the new compounds were elucidated by detailed analysis of HRESIMS, NMR, CD, and ECD data. Compound 3 showed potent PTP1B inhibitory activity with an IC50 value of 7.9 μM (ursolic acid as positive control, IC50 = 8.3 μM).

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Disclosure statement

The authors declared that they have no conflicts of interest to this work.

Additional information

Funding

This research was financially supported by the National Key Research and Development Program of China (Nos. 2018YFC1406705 and 2018YFC0310900), the Shanghai Pujiang Program (No. 2020PJD082), the Natural Science Foundation of Shanghai (No. 20ZR1470600), and the National Natural Science Foundation of China (Nos. 41606173 and 81741152).

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