Cytotoxic lanostane triterpenoids from the ethanol extract of Schisandra viridis

Abstract

Three new lanostane triterpenoids, designated as 6-hydroxyl schiglausin A (1), 29-hydroxyl schiglausin D (2), and 6-hydroxyl schiglausin G (3), were isolated from the ethanol extract of the stems of Schisandra viridis. Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activities. As a result, compound 1 exhibited cytotoxic activities for all six tested human lung cancer cell lines with IC₅₀ values less than 10 μM.

Graphical abstract

Keywords:

• Schisandraceae
• Schisandra viridis
• lanostane triterpenoids
• cytotoxicity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was funded by 2019 Nantong Science and Technology Plan Guidance Project (MSZ19192).