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Articles

New lignans and diterpenoid glycosides from the fruits of Xanthium italicum Moretti

, , , , , , & show all
Pages 518-527 | Received 08 Mar 2021, Accepted 31 May 2021, Published online: 02 Jul 2021
 

Abstract

A pair of new lignans [(+)- 1 and (-)- 1] and three new compounds (2-4), together with a known compound 5, were isolated from the fruits of Xanthium italicum Moretti. The structures of these compounds were determined on the basis of spectroscopic analysis, particularly HR-ESI-MS and 1 D and 2 D NMR. Compounds 2 and 3 showed antinociceptive effects in an acetic acid-induced writhing test in mice with the writhe inhibition rates of 80.50% and 67.89% at the dose of 20 mg/kg, respectively.

Acknowledgments

We are grateful to the Department of Instrumental Analysis, Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College for measuring the IR, NMR, MS and HRESIMS.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Natural Science Foundation of China (Grant number No. 81573321).

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