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Journal of Asian Natural Products Research Volume 24, 2022 - Issue 3
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Articles

Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats

Ran YangBeijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaORCID Iconhttps://orcid.org/0000-0002-0394-3499View further author information
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Yan-Jia ShenBeijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaORCID Iconhttps://orcid.org/0000-0002-4887-0975View further author information
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Miao ChenBeijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaORCID Iconhttps://orcid.org/0000-0002-9195-8542View further author information
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Jia-Ying ZhaoBeijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaORCID Iconhttps://orcid.org/0000-0002-9907-5023View further author information
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Shu-Han ChenBeijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaORCID Iconhttps://orcid.org/0000-0002-1873-7540View further author information
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Wen ZhangBeijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaORCID Iconhttps://orcid.org/0000-0002-1817-8873View further author information
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Jun-Ke SongBeijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaORCID Iconhttps://orcid.org/0000-0002-4379-0909View further author information
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Li LiBeijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-6246-6605View further author information
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Guan-Hua DuBeijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing100050, ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-6896-0847View further author information
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Pages 278-289 | Received 24 Mar 2021, Accepted 25 Jun 2021, Published online: 22 Jul 2021
 
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Abstract

The purpose of the present study was to examine the protective action and mechanisms of quercetin on the blood-brain barrier (BBB) in rats subjected to transient middle cerebral artery occlusion (tMCAO) and reperfusion. Quercetin (10, 30, 50 mg/kg) was intraperitoneally administered at the onset of reperfusion. The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway. Moreover, EX527, a selective inhibitor of Sirt1, reversed these neuroprotective effects. Our findings indicate that quercetin has neuroprotective effects against cerebral ischemia-reperfusion injury by protecting BBB through Sirt1 signaling pathway in MCAO rats.

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Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was financially supported by grants from CAMS Innovation Fund for Medical Sciences (CIFMS) (2016-I2M-3-007, 2017-I2M-1-010), Major Scientific and Technological Special Project for “Significant New Drug Creation” (2018ZX09711001-003-005), the National Natural Science Foundation of China (81102444, 82073863, 82004071) and the China Scholarship Council (201808110107).

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