Chemical constituents from the stems of Acanthopanax senticosus with their cytotoxic activities

Abstract

A new coumestan named 7,5'-dihydroxy-4'-(3''-hydroxy-3''-methyl-trans-isobut-1''-enyl) coumestan (1), together with five known compounds (2–6), was isolated from the EtOAc-soluble extract of the stems of Acanthopanax senticosus. Their structures were elucidated based on extensive spectroscopic analyses. All the isolates were evaluated for in vitro cytotoxic activities against four human cancer cells including HepG2, A549, HeLa and MCF-7. Among them, the new compound 1 was found to exhibit significant cytotoxic activity on HeLa cells with IC₅₀ value of 6.5 μM.

Keywords:

• Acanthopanax senticosus
• Araliaceae
• coumestan
• cytotoxic activity

Acknowledgements

We thank to the workers of Kunming Biotechnology Co., Ltd, and the colleagues of the Research Center for Chemistry, Guangzhou University of Chinese Medicine.

Disclosure statement

No potential conflict of interest was reported by the authors.