Three new polyketide derivatives of the endophytic fungus Aspergillus cristatus 2H1

Abstract

Three new polyketide derivatives, 2-ethoxycarbonyl-endocrocin (1), 6-methoxy-2-ethoxycarbonyl-endocrocin (2) and pannorin C (3), along with sixteen known compounds (4–19) were isolated from a plant endophytic fungus Aspergillus cristatus 2H1. Their structures were elucidated by 1D/2D NMR and HR-ESI-MS data analysis. Compound 3 showed weak antibacterial activity against Staphylococcus aureus (MIC 20 μg/ml). Compounds 14 and 15 showed effective cytotoxicity on human melanoma A375 cells (IC₅₀ 4.13 μM for 14, 3.39 μM for 15).

Graphical Abstract

Keywords:

• Aspergillus cristatus
• polyketide derivatives
• antibacterial activity
• antitumoral activity

Disclosure statement

These authors have no conflict of interest to declare.

Additional information

Funding

This work was sponsored by National Key R&D Program of China (2018YFC1706200), NSFC (81991524 and 82174089), and Qing Lan Project and Postgraduate Research & Practice Innovation Program (KYCX20_1610).