Two new iridoid glycosides from Hedyotis diffusa

Abstract

Two new iridoid glycosides, named productasperulosidic acid butyl ester (1) and E-6-O-3-hydroxy-p-methoxycinnamoyl scandoside methyl ester (2), along with nine known ones (3–11), were isolated from Hedyotis diffusa Willd. The structures of them were elucidated by extensive 1D, 2D NMR and HR-ESI-MS spectral data. Compounds 1–11 showed no significant cytotoxic activity against HeLa cells.

Graphical Abstract

Keywords:

• Rubiaceae
• Hedyotis diffusa
• iridoid glycoside
• asperulosidic acid butyl ester
• E-6-O-3-hydroxy-p-methoxycinnamoyl scandoside methyl ester
• cytotoxic activity

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (31660102, 21572082, 82073737), the Innovative Team of Yunnan Province (No. 2019HC018), and the fund of Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization (FPRU2016-8).