https://orcid.org/0000-0002-6872-6284
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Abstract
A phytochemical investigation of Menispermum dauricum led to the isolation of five oxoisoaporphine-type alkaloids (1–5) and five aporphine-type alkaloids (6–10), including a novel oxoisoaporphine-type alkaloid: menispeimin A (1). Their structures were elucidated by spectroscopic studies including MS, 1 D and 2 D NMR, and confirmed by comparing with literature data. Among them, alkaloids 4–10 were obtained for the first time from Menispermum genus. Natural products 2, 4 and 6 exhibited significant cytotoxic activity against A549, Bel-7402 and MCF-7 cell lines.
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Disclosure statement
No potential conflict of interest was reported by the author(s).
Additional information
Funding
The investigation was supported by grants from the National Natural Science Foundation of China (81973218), Taishan Industry Leading Talents Project (202103), Technology Development Program of TCM of Shandong Province (2019-0024) and Open Projects Fund of NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate-based Medicine (2021QRECM02).