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Abstract
Two new sesquiterpenoids (1 and 3), one new natural product (2), and two known compounds (4 and 5) were isolated from the leaves of Chimonanthus nitens. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of compound 3 was determined by the X-ray single-crystal diffraction analysis. The cytotoxicity of compounds 1-5 was evaluated at three concentrations on two human breast cancer cell lines (MDA-MB-468 and MDA-MB-231) by MTT assay. As a result, we found that the cytotoxicity was weak even with a concentration of these compounds up to 100 μM.
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Disclosure statement
No potential conflict of interest was reported by the authors.
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Funding
The work was financially supported by the National Natural Science Foundation of China (N0. 81360631) and Project of the Key Research and Development Program for Jiangxi Province (No. 20203BBGL73218).