Two new compounds from Verbena bonariensis

Abstract

Two new compounds verboncin A (1) and verboncin B (4) and 14 known compounds (2–3 and 5–16) were isolated from Verbena bonariensis, and these 14 compounds were first obtained from this plant. Their chemical structures were established by one and two-dimensional NMR and HRESIMS analysis and the results were compared with literature values. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD). The cytotoxicity of some of the compounds against MCF-7, HCT-116, MDA-MB-231, and SW620 human cancer cell lines were evaluated, in which compound 4 showed negligible cytotoxic activity with an IC₅₀ value of 68.08 ± 0.35 µM against the MCF-7 cell line.

 

Keywords:

• Verbenaceae
• Verbena bonariensis
• iridoid
• sterol

Acknowledgements

The authors thank the Advanced Analysis and Measurement Center of Yunnan University for the sample testing service.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China [21762048, 81860615, 82260682, 81903541 and 22167021]. Applied Basic Research Foundation of Yunnan Province [2018FY001, 2018FA048, 202101AT070864 and 202101AT070195], the Program for Changjiang Scholars and Innovative Research Team in University [IRT_17R94], Project of Innovative Research Team of Yunnan Province [202005AE160005], and Yun Ling Scholar Project to Wei-Lie Xiao, National Key R&D Program of China [2019YFE0109200], and a grant [no. 2021KF004] from YNCUB.