Diterpenoid alkaloids from two species of Delphinium

Abstract

Four new compounds (1–4) were isolated from the whole plants of two species of Delphinium, including two C₂₀-diterpenoid alkaloids, umbrodines A and B (1 and 2), and a dibenzoxazepinone, umbrolide A (3) from Delphinium umbrosum Hand.-Mazz. and a C₂₀-diterpenoid alkaloid, kingiadine (4) from Delphinium kingianum Bruhl. ex Huth. Ten known diterpenoid alkaloids were also isolated. Their structures were elucidated via HR-ESIMS, IR, and NMR data. Lycoctonine (11) and delectinine (12) exhibited appreciable cardiac activity. Furthermore, 11 and 12 showed cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells, with the maximum protection rates of 61.63% and 51.18%, respectively.

Graphical Abstract

Keywords:

• Ranunculaceae
• Delphinium kingianum
• Delphinium umbrosum
• cardiotonic activity
• H9c2 cells
• cardioprotective effects

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the National Natural Foundation of China [82073734] and the Fundamental Research Funds for Central Universities [2682022ZTPY078].