Two new dihydro-β-agarofuran sesquiterpenes from the roots of Celastrus angulatus

Abstract

Two new dihydro-β-agarofuran sesquiterpenes chiapen T (1) and chiapen U (2), along with chiapen A (3), 1β-hydroxy-2β,6α,12-triacetoxy-8β-(β-nicotinoyloxy)-9β-(benzoyloxy)-β-dihydroagarofuran (4), wilforlide B (5), 3-hydroxy-2-oxo-3-friedelen-29-oic acid (6), epikatonic acid (7), 22-epi-maytenfolic acid (8), maytenoic acid (9), wilforic acid F (10), wilforic acid B (11), were reported for the first time from the Celastrus angulatus. The structures of all the compounds were elucidated by HR-ESI-MS, 1 D and 2 D NMR spectra, as well as single-crystal X-ray diffraction analyses. Compounds 1 and 2 were examined for anti-inflammatory activity, respectively. None of them showed potent activity.

Graphical Abstract

Keywords:

• Celastraceae
• Celastrus angulatus
• dihydro-β-agarofuran sesquiterpenes
• single-crystal X-ray diffraction

Acknowledgments

The authors are grateful to Dr. ZY. Zhang at Shanghai Institute of Materia Medica for the crystallographic data collection. The authors thank the Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences for the measuring the IR, NMR, MS and HR-ESI-MS.

Disclosure statement

No conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by National Adiministration of Traditional Chinese Medicine [No. 040180043] and Guizhou University of Traditional Chinese Medicine [No. 04021016107].