Echinacoside exerts its protective effects in a type 2 diabetes mellitus injury model via the AKT pathway

Abstract

Echinacoside (ECH) is the main compound of Cistanche deserticola, which possesses antioxidant, antitumor, antifatigue, and anti-inflammatory properties. The present study investigated the protective effects of echinacoside on type 2 diabetes mellitus (T2DM)-induced injury in T2DM injury db/db mice model and insulin-resistant LO₂ cell model. The results demonstrated that ECH probably alleviated T2DM-induced injury by mediating the AKT pathway, which provided a new direction for the treatment of T2DM-induced injury.

Graphical Abstract

Keywords:

• ECH
• T2DM
• AKT
• insulin resistance
• glucose

Acknowledgments

The authors acknowledge the Experimental Center of Dahua Hospital for the support of animal experiment technology.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was financially supported by the Shanghai Municipal Health and Family Planning Commission Foundation [grant number 201740224].