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Journal of Asian Natural Products Research Volume 25, 2023 - Issue 9
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Chemical constituents from the stem bark of Albizia julibrissin and their SREBP-1c inhibitory activity

Meiling Xiana Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon21983, KoreaView further author information
,
Mira Oha Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon21983, KoreaView further author information
,
Hee Jae Kwaka Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon21983, KoreaORCID Iconhttps://orcid.org/0000-0001-6171-2552View further author information
ORCID Icon,
Hyunjin Jeongb Department of Pharmacy, Kangwon National University, Chuncheon24341, KoreaView further author information
,
Hyun-Jeong Kob Department of Pharmacy, Kangwon National University, Chuncheon24341, KoreaView further author information
&
Seung Hyun Kima Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon21983, KoreaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2613-0674View further author information
ORCID Icon
Pages 912-917 | Received 03 Sep 2022, Accepted 25 Dec 2022, Published online: 04 Jan 2023
 
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Abstract

One new lignan, julibrissinoside II, along with thirteen known compounds, was isolated from the stem bark of Albizia julibrissin. The structure of julibrissinoside II was determined on the basis of extensive spectroscopic methods, including NMR and CD spectroscopic data. The isolated compounds were tested for their SREBP-1c inhibitory activity at different concentrations using mouse hepatocyte AML12 cell lines. Among them, linoleic acid (2) and 3-O-methylfisetin (4) showed significant SREBP-1c inhibitory activity at the concentration of 100 µM.

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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was financially supported by the National Research Foundation of Korea (NRF) [2020R1A2C1012632].

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