Cadinane sesquiterpenes from the stems and branches of Illicium ternstroemioides

Abstract

Three new cadinane sesquiterpenes (1–3) and three known sesquiterpenes were isolated from the stems and branches of Illicium ternstroemioides A. C. Smith. The structures of the new compounds were elucidated by extensive analysis of spectroscopic and HRESIMS data. The structures of illiternins A–C (1–3) were confirmed by single crystal X-ray diffraction, allowing for the determination of their absolute configurations. Compounds 3 and 6 exhibited antiviral activity against Coxsackievirus B3 with IC₅₀ values of 33.3 and 57.7 μM, respectively.

Keywords:

• Illicium ternstroemioides
• Illiciaceae
• cadinane
• sesquiterpenes
• antiviral
• Coxsackievirus

Acknowledgements

We are grateful to the Department of Instrumental Analysis at our institute for obtaining NMR spectra and to the State Key Laboratory of Natural and Biomimetic Drugs of Peking University for the X-ray crystallographic measurements and analyses. The authors are grateful to the Department of Instrumental Analysis at our institute for the spectroscopic measurements.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was funded by the National Natural Science Foundation of China [22177135].