Oxidative Aromatization of 1,3,5-trisubstituted 2-pyrazolines Using Oxalic Acid/Sodium Nitrite System

ABSTRACT

Oxidative aromatization of 1,3,5-trisubstituted 2-pyrazolines by in-situ generation of NO⁺ from oxalic acid/sodium nitrite system has been described. The main advantages of this procedure are the use of an inexpensive and readily available catalyst, facile work-up, and improved yields in aqueous ethanol.

KEYWORDS:

• 1,3,5-trisubstituted 2-pyrazolines
• oxalic acid
• oxidative aromatization
• sodium nitrite

Funding

The authors thank the Research Council of Hakim Sabzevari University for partial support of this work.