An Efficient and Green Synthesis of 1′Hspiro[isoindoline-1,2′-quinazoline]-3,4′(3′H)-dione Derivatives in the Presence of Nano Fe₃O₄–GO–SO₃H

ABSTRACT

In this article a simple, rapid, green and efficient method for the synthesis of various 1′Hspiro[isoindoline-1,2′-quinazoline]-3,4′(3′H)-diones in the presence of acidic magnetic graphene oxide nanosheets (Fe₃O₄–GO–SO₃H) as catalyst is reported. Different substituted spirooxindoles have been synthesized from one-pot three component reaction of isatoic anhydride, aliphatic or aromatic primary amines and isatin in the presence of Fe₃O₄–GO–SO₃H. This reaction allowed us to prepare some new and known derivatives of substituted spirooxindoles. The worthwhile advantages of this method are high product yields, short reaction times, the possibility of using of a magnetic, reusable and non-toxic catalyst and solvent-free conditions.

KEYWORDS:

• Magnetic graphene oxide
• one-pot reaction
• solid acid catalyst
• spirooxindoles
• solvent-free

Funding

The authors are grateful to K. N. Toosi University of Technology Research Council for supporting this work.