Efficient Multicomponent Approach to the Medicinally Relevant 5-aryl-chromeno[2,3-b]pyridine Scaffold

ABSTRACT

The general multicomponent approach was found to the medicinally relevant 5-aryl-chromeno[2,3-b]pyridine scaffold. Triethylamine catalyzed multicomponent reaction of benzaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and dimedone in a minimal amount of propanol results in efficient formation of substituted 2,4-diamino-8,8-dimethyl-6-oxo-5-aryl-6,7,8,9-tetrahydro-5H-chromeno[2,3-b]pyridine-3-carbonitriles in 75–80% yields. This general and efficient approach avoids traditional recrystallization and chromatographic purification stages and opens a convenient way to scaffolds, promising for many diverse oriented medical applications.

KEYWORDS:

• 2-Aminoprop-1-ene-1,1,3-tricarbonitrile
• benzaldehyde
• catalysis
• chromeno[2,3-b]pyridine
• dimedone
• multicomponent reaction

Funding

The research was supported by the Council at President of Russian Federation authors (Project MD-380-2017.3).