Synthesis of Tetrahydrotriazoloacridine Derivatives Using an Efficient and Reusable Poly-Organocatalyst

ABSTRACT

The condensation of 5-amino-1H-benzotriazole and 5,5-dimethylcyclohenxane-1,3-dione with aryl aldehydes was efficiently promoted in the presence of poly(N-vinylimidazole) in ethanol at reflux condition. This method is efficient to synthesize 11-aryl-8,8-dimethyl-6,7,9,11-tetrahydro[1,2,3]triazolo[4,5-a]acridine-10(1H)-ones in good to excellent yields that are characterized by the analytical and spectral data. The poly-organocatalyst can be recycled and reused up to three times without significant loss of activity. This one-pot three-component reaction provided an efficient method for the synthesis of aromatic heterocycles with a variety of biological and pharmacological properties.

KEYWORDS:

• One-pot multicomponent reaction
• poly-organocatalyst
• recyclability
• tetrahydroacridine

Acknowledgments

The authors are thankful to the Research House of Professor Reza, Education Guilan, and Malaya University for partial support of this work.