Melamine: An Efficient Promoter for Some of the Multi-component Reactions

Abstract

Melamine, as an inexpensive and commercially available reagent, can be efficiently used for the promotion of the synthesis of 3,3′-(4-arylmethylene) bis-(4-hydroxycoumarins), 2,2′-arylmethylene bis(3-hydroxy-5,5-dimethyl-2-cyclohexene-1-ones) and 2-amino-4H-chromene derivatives. In addition to the mild conditions, this method provides other important advantages including simple work-up procedure, environmental friendliness, short reaction times, high yields of the products and use of a cheap, stable and reusable catalyst.

Keywords:

• Bis-coumarins
• chromenes
• melamine
• mild reaction conditions
• tetraketones

Acknowledgments

We are thankful to the University of Guilan Research Council for the partial support of this work.

Disclosure statement

No potential conflict of interest was reported by the authors.