Preparation of Magnetic Cu(II) Nano-structure (Based on Nano-Fe₃O₄) and Application to the Synthesis of Hexahydroquinoline Derivatives

Abstract

A nanomagnetic catalyst based on the nano-Fe₃O₄ core was synthesized and used in the synthesis of the hexahydroquinoline derivatives which acts as a solid heterogeneous catalyst. The as-prepared catalyst was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, vibrational sample magnetometry, and thermal gravimetric analysis. Catalyst activity was tested in the synthesis of hexahydroquinoline derivatives. The FTIR shows that the catalyst can activate as the carbonyl group of the benzaldehyde, so that it can motivate the reaction. The proposed method has important features which include solvent free, mild, high yield, shorter reaction time, easy preparation and separation of the catalyst, and efficient workup procedure. On the other hand, the design of experiment was used as a systematic method for the programing of the reaction condition. Optimization showed that the optimal reaction temperature and amount of catalyst were 65 °C and 0.05 g, respectively.

Keywords:

• Hexahydroquinolines
• one-pot reaction
• nanomagnetic
• nano-Fe₃O₄

Acknowledgement

Thank you to Dr. Hassan Soodmand Afshar for his valuable contributions to increase the content of sincerity.

FUNDING

The authors gratefully acknowledge partial support of this work by the Research Affairs Office of Bu-Ali Sina University (Grant number 32-1716 entitled development of chemical methods, development of chemical methods, reagents and molecules; reagents and molecules) and Center of Excellence in Development of Chemical Method (CEDCM), Hamedan, I. R. Iran.

Additional information

Funding

The authors gratefully acknowledge partial support of this work by the Research Affairs Office of Bu-Ali Sina University (Grant number 32-1716 entitled development of chemical methods, development of chemical methods, reagents and molecules; reagents and molecules) and Center of Excellence in Development of Chemical Method (CEDCM), Hamedan, I. R. Iran.