Synthesis, Antimicrobial and Anticancer Evaluations of Novel Thiazoles Incorporated Diphenyl Sulfone Moiety

Abstract

A novel series of thiazoles incorporated phenylsulfonyl group have been designed and synthesized from the treatment of N-(1-(4-(phenylsulfonyl)phenyl)ethylidene)hydrazine carbothioamide with various types of α-halocarbonyl compounds in one-pot reaction strategy under microwaves irradiations. Studying all possible spectral data for the prepared compounds were proved their structure as well as the suggested mechanism of their reactions. The results of antimicrobial activity of some selected derivatives proved their potency in which some derivatives showed activity exceeded the activity of the reference drugs. In addition, selected derivatives were investigated for their anticancer activities against HepG-2 and HCT-116 cell lines to shed some light on the anticancer activity of the newly synthesized thiazole derivatives. One of the tested thiazole derivatives showed good activity in comparison with doxorubicin reference.

Graphical Abstract

Keywords:

• Antimicrobial activity
• phenyl sulfones
• thiazoles
• thiosemicarbazone
• α-halocarbonyl compounds

Disclosure statement

There are no conflicts of interest.

Additional information

Funding

All authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work (Project code: 18-SCI-5-06-0005).