Abstract
A convenient approach for the synthesis of diversely functionalized [1,2,4]triazolo[5,1-f]purine heterocyclic framework have been accomplished. The products were obtained through the combination of 5-amino-3-(methylthio)-1H-1,2,4-triazole with 5-bromo-2,4-dichloro-6-methylpyrimidine followed by a SNAr alkoxylation of the novel tricyclic heterocyclic core with various aliphatic alcohols. All newly synthesized heterocycles were fully elucidated by both computational and spectral evaluations.