An Efficient One-Pot Synthesis of 6-Phenyl-3-(1H-Pyrazol-1-yl)-[1,2,4]Triazolo[3,4-b][1,3,4]Thiadiazole Derivatives and Their Antimicrobial Evaluation and Molecular Docking Studies

Abstract

An efficient rapid synthesis of a new class of diversely functionalized 6-phenyl-3-(1H-pyrazol-1-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (4a–q) is described via a facile one-pot, three-component cascade reaction with high yields. It is a multi-functional cyclization reaction to form two new heterocycles. The structures of newly formed compounds were confirmed by using spectral and analytical studies. Simple reaction conditions, the good isolated yield of the product, and no column chromatographic purification are attractive features of the present protocol. Further, the newly synthesized compounds were screened for anti-microbial activity and molecular docking interactions.

Keywords:

• Triazole
• pyrazole
• thiadiazole
• multi-component reaction
• docking studies
• anti-microbial

Acknowledgments

The authors are thankful to the Head of the Department of Chemistry and Director of the National Institute of Technology, Warangal, Telangana, for providing infrastructure facilities, and one of the authors P. C. Jilloju is thankful to the MHRD Government of India, for providing research fellowship.

Disclosure statement

No potential conflict of interest was reported by the authors.