One-Pot Multicomponent Synthesis of 3-Methyl-4-(Hetero)Arylmethylene Isoxazole-5(4H)-Ones Using Guanidine Hydrochloride as the Catalyst under Aqueous Conditions

Abstract

Here, we have developed an expeditious and efficient protocol for the synthesis of isoxazole-5(4H)-ones derivatives using guanidine hydrochloride as a catalyst using water as a solvent. The one-pot multicomponent reaction of aldehydes, ethyl acetoacetate, and hydroxylamine hydrochloride at room temperature to give a 3-methyl-4-(hetero)arylmethylene isoxazole-5(4H)-ones derivatives in an excellent yield. The key advantages of the reported method are shorter reaction time, energy-efficient, easy work-up procedure, wide substrate scope tolerance, economical, etc. further the catalyst was recycled up to 5 times along with high product yield without significant loss of its catalytic activity.

Graphical Abstract

Keywords:

• Aldehydes
• guanidine hydrochloride (GuHCl)
• isoxazole
• one-pot multicomponent
• water R.T

Disclosure statement

The authors declare no competing financial interest.

Author contributions

The manuscript was written through the contributions of all authors. All authors have approved the final version of the manuscript.

Additional information

Funding

This article was funded by TEQIP III.