Phosphorylation of 2-Aryl Quinoxaline Derivatives via C-H/P-H Cross Coupling under Transition-Metal-Free Conditions

Abstract

In this study, we have developed an efficient protocol for synthesis of phosphorus-substituted heterocycles through reaction between 2-Aryl quinoxalines and dialkyl phosphites under transition-metal-free conditions. Here, K₂S₂O₈ has been used as the sole oxidant for the facile synthesis of phosphorus substituted derivates. A variety of heteroaryl phosphonate derivatives have been synthesized under optimized conditions in good to excellent yields with this facile and environment friendly protocol.

Keywords:

• Phosphorus-substituted heterocycles
• 2-Aryl quinoxalines
• dialkyl phosphites
• C-H activitaion

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This research was supported by the Research Council of the University of Tehran.