Synthesis of Functionalized-Magnetic Nanoparticles and Application as a Retrievable and Efficient Catalyst for the Green Synthesis of Pyrano[2,3-c]Phenazine-15-yl)Methanone Derivatives Under Solvent-Free Conditions

Abstract

A novel method for the synthesis of four-component pyrano[2,3-c]phenazin-15-yl) methanone derivatives has been developed via condensation/Knoevenagel/Michael in the presence of Fe₃O₄@ZnO-SO₃H as a recyclable heterogeneous catalyst under Solvent-Free Conditions, using microwave irradiation. This green process has many advantages such as high productivity, shorter reaction times, environmentally friendly, quick isolation, and prevention of hazardous solvents in the laboratory for the synthesis of pyrano[2,3-c]phenazin-15-yl)methanone derivatives, which are promising compounds in various aspects of medical sciences (pharmacy).

Graphical Abstract

Keywords:

• Multi-component reaction
• solvent-free
• arylglyoxal
• microwave irradiation
• condensation
• recyclable catalyst

Acknowledgments

We gratefully acknowledge financial support from the Research Council of the University of the Islamic Azad University of Yazd.

Disclosure statement

No potential conflict of interest was reported by the author(s).