Abstract
A new series of 6,9-dihydrofuro[3,2-f]quinoline-8-carbonitrile derivatives were prepared, via one-pot reaction of ethyl 5-aminobenzofuran-2-carboxylate, aromatic aldehydes and 3-oxo-3-phenylpropanenitrile in ethanol as a solvent at reflux. The advantages of this protocol include mild reaction conditions, easy purification, high yields, and catalyst-free approach. IR, 1H NMR, 13C NMR and HRMS spectras were used to identify the structures of all the synthesized compounds.
Graphical Abstract
![](/cms/asset/4e925e74-534d-4031-a2ae-8b547a59f5ec/gpol_a_1988996_uf0001_c.jpg)
Acknowledgement
We are grateful to the Natural Science Foundation for Colleges and Universities of Jiangsu Province (18KJB150024), Science and Technology Development Fund of Kangda College of Nanjing Medical University (KD2020KYJJZD072) and Innovation training program projects for the students of Kangda College of Nanjing Medical University for financial support.