Synthesis and Evaluation of a New Series of Antileishmanial Agents

Abstract

A series of oximinoethers of indanone/aryloxy indanone were synthesized and screened for its in vitro antileishmanial activity profile (in promastigote and amastigote models) against Leishmania donovani, the causative agent of leishmaniasis. Compounds 3a–d, 4a–d, 5a, 5b, 6a–d & 7a–d have shown 87–100% inhibition against promastigotes and 47–100% inhibition against amastigotes at a concentration of 05 μg/ml. compounds 3a, 4a–b, 6b–c, 7a–d and 4b, 4d, 6c–d exhibited 100% inhibition against promastigotes and amastigotes respectively.

Graphical Abstract

KEYWORD:

• Antileishmanial activity
• aryloxy indanone
• indanone
• oximinoethers

Acknowledgments

The authors are grateful to the Department of Postgraduate Studies and Research in Chemistry, Dnyanopasak College, Parbhani and Shri Chhatrapati Shivaji College, Omerga, India, for providing laboratory facilities and Indian Institute of Chemical Technology, Hyderabad for spectral analysis.

Disclosure statement

No potential conflict of interest was reported by the authors.