Novel One-Pot Pseudo-Five-Component Green Synthesis and Biological Activities In Vitro of 5,5′-(Arylmethylene)Bis (4-Hydroxythiazol-2(3H)-One) Using Triton-X-100 as High Efficient Catalytic System

Abstract

Synthesis of 5,5′-(arylmethylene)bis(4-hydroxythiazol-2(3H)-one) by a three-component condensation of an aldehyde, monochlroacetic acid and thiourea in the presence of a nonionic surfactant Triton X-100 catalyst at room temperature in aqueous medium is accomplished. The advantages are high yield, mild reaction conditions, simple work-up and eco-friendliness. All the newly-synthesized compounds (4a–r) exhibited moderate in vitro antibacterial and antifungal activities.

Graphical Abstract

Keywords:

• 5,5′-(arylmethylene)bis(4-hydroxythiazol-2(3H)-one)
• Triton X-100
• three-component reaction
• nonionic surfactant
• thiourea

Acknowledgment

This work was supported by grants from the research council of Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran and Payame Noor University, Tehran, Iran.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

Qaemshahr Islamic Azad University, Iran and Payame Noor University, Tehran, Iran.