Microwave Irradiation–Mediated Synthesis of New Substituted Pyridopyrimidines via the Suzuki–Miyaura Coupling Reaction and Biological Evaluation

Abstract

In this work, an eco-friendly, effective and easy route to synthesize substituted pyridopyrimidines is reported starting from 4-methylsulfanylpyrido[3,2-d]pyrimidines that undergo a Suzuki–Miyaura coupling reaction under microwave irradiation. In this work, initially, the chlorinated intermediate was prepared from the available chemical reagents. The prepared compounds were effectively synthesized by reacting the chlorinated intermediate with versatile boronic acids. The resulting products were tested for their antimicrobial efficiency against different microbes. In this way, three synthesized derivatives were found to be active against the studied bacterial strains. Unfortunately, the derivatives were found to be inactive against the studied fungus.

Graphical Abstract

Keywords:

• Pyrido[3,2-d]pyrimidines
• micro-wave irradiation
• antimicrobial activity
• Suzuki-Miyaura
• microwave

Acknowledgment

The authors extend their appreciation to the Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number (IF-PSAU-2021/03/17735).

Additional information

Funding

The authors extend their appreciation to the Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number (IF-PSAU-2021/03/17735)