Synthesis of β-Amino Alcohols from Value-Added Plant-Polyphenols Using ACC as a Green Reaction Medium and Mechanistic Study from DFT Analysis

Abstract

A simple, new, and cost-efficient alternative route has been designed for the synthesis of unique β-amino alcohols under metal-free condition from new type of 1,2- disubstituted styrene epoxides obtained from substituted p-hydroxycinnamic acids via greener approach. It was followed by density functional theory (DFT) based computational study to investigate the mechanistic path for generating acetylated amino alcohols i.e. the main key step for the formation of β-amino alcohols.

Graphical Abstract

Keywords:

• Epoxides
• aromatic amines
• p-hydroxy cinnamic acids
• β-amino alcohols
• TMG

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work is financially supported by UGC, New Delhi [Ref. No.- 21/06/2015(i)EU-V]. F.B. and G.J. acknowledges Department of Chemistry, Indian Institute of Technology Kharagpur, India where the work discussed in this paper is carried out.