Cu-Modified Magnetic Creatine as an Efficient Catalyst for Regioselective Preparation of 1,2,3-Triazoles Derivatives

Abstract

The present study focuses on Fe₃O₄@Creatine@Cu catalyzed one three-component reaction called “click reaction” to synthesize 1,2,3-triazoles. Therefore, a mild and green synthesis was developed for 1,3-dipolar cycloaddition reactions of several various azides and alkynes. This cycloaddition is a strong synthetic instrument in the creation of a heterocyclic ring, with wide usages in various fields. Creatine derivative functional groups were linked to the magnetic nanostructure as an efficient ligand by high amounts of oxygen and nitrogen to improve the catalyst action. Afterwards, Cu(II) ions were attached to the surface of the magnetic creatine structure to gain the last catalyst; then, this catalyst was characterized using some analysis methods, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and energy-dispersive X-ray analysis (EDX). The recycled catalyst was performed five times without any considerable decrease in catalytic magnetic properties and efficiency. Significant advantages of this procedure include high speed, mild condition, reusability, high yield, and affordability which make this method attractive.

Keywords:

• Creatine
• click reaction
• triazoles
• green chemistry

Acknowledgments

The authors appreciate the University of Mazandaran (UMZ) for its financial help in doing the experiments.