Synthesis of Pyrazolopyranopyrimidine and Dihydropyrano[2,3-c]Pyrazole Derivatives Using Fe₃O₄@THAM-Piperazine as a Superparamagnetic Nanocatalyst under Green Condition

Abstract

In this article, a new and simple procedure was designed for the preparation of pyrazolopyranopyrimidine and dihydropyrano[2,3-c]pyrazole derivatives using the reaction between hydrazine hydrate, aryl aldehydes, malononitrile or barbituric acid, and ethyl acetoacetate using Fe₃O₄@THAM-piperazine as a solid nanocatalyst in a solution of water and ethanol at 60 °C. The present process offers advantages like easy workup, short reaction time, non-toxicity, and the use of green solvent. Moreover, recyclability studies were carried out that showed a high potential of reusing and recovering capability.

Graphical Abstract

Keywords:

• Dihydropyrano[2,3-c]pyrazole
• Fe₃O₄@THAM-piperazine
• green condition
• pyrazolopyranopyrimidine
• superparamagnetic nanocatalyst

Acknowledgments

The authors gratefully appreciate the financial support from the Research Council of University of Sistan and Baluchestan.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors gratefully appreciate the financial support from the Research Council of University of Sistan and Baluchestan.