Abstract
A simple microwave assisted tungstophosphoric acid (H3PW12O40) catalyzed protocol was employed for the synthesis of versatile enaminoketones. The developed synthetic procedure is green, efficient and environmentally benign. Using this method, a series of enaminoketones were prepared from the condensation of dimedone and various amines. Further, the synthesized enaminoketones were evaluated for in-vitro anti-inflammatory activity by membrane stabilization method and anti-oxidant efficacy by radical scavenging method. The synthesized enaminoketones 3c, 3b and 3b, 3f showed reasonable anti-inflammatory as well as anti-oxidant activities respectively.
Graphical Abstract
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Acknowledgment
The author ML acknowledges SIF-VIT for the support and Dr. Gokulnath from IISER, Kerala for single crystal XRD analysis.
Disclosure statement
No potential conflict of interest was reported by the author(s).