A New Approach for the Synthesis of Bis(3-Indolyl)Pyridines via a Cooperative Vinylogous Anomeric Based Oxidation Using Ammonium Acetate as a Dual Reagent-Catalyst Role under Mild and Green Condition

Abstract

Herein, we introduced a new method for the synthesis of bis(3-indolyl)pyridines. Accordingly, ammonium acetate was introduced as a dual reagent-catalyst role, for preparation of bis(3-indolyl)pyridines without using any toxic solvents and co-catalysts. Also, the cooperative vinylogous anomeric based oxidation (CVABO) theory plays a synergistic effect for the aromatization of final product. The final structure of products has been verified using FT-IR and ¹H-NMR, ¹³C-NMR techniques.

Graphical Abstract

Keywords:

• Ammonium acetate
• anomeric effect
• bis(3-indolyl)pyridine
• dual reagent-catalyst role
• multicomponent reactions

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

We thank the Bu-Ali Sina University and Iran National Science Foundation (INSF) [Grant Number: 4004528] for financial support.