An Attractive and Efficient Procedure for Synthesis of Heterocyclic Structures: MNPs-Bis(2-Hydroxyethyl)-Guanidine-Ni Nanocomposite as a Novel and Green Nanomagnetic Catalyst for Multicomponent Reactions

Abstract

Now, in this paper, we report the successful fabrication of MNPs-bis(2-hydroxyethyl)-guanidine-Ni nanocatalyst and study its catalytic behavior for the synthesis of pyrano[2,3-c]pyrazoles and highly functionalized piperidines. The Structure of the as-fabricated MNPs-guanidine-bis(ethanol)-Ni nanomaterial was fully characterized by advanced microscopic and spectroscopic methods, such as FT-IR, SEM, TEM, EDX, TGA, VSM, XRD and ICP-OES. With aryl aldehydes, ethyl acetoacetate, and aniline or malononitrile and hydrazine hydrate as the reactive species, the created MNPs-bis(2-hydroxyethyl)-guanidine-Ni catalytic agent acts as a promising candidate to deliver numerous pharmaceutically relevant highly functionalized piperidines and pyrano[2,3-c]pyrazoles scaffolds. The developed methodology comes with a host of advantageous features, such as gentle reaction conditions, a broad substrate range, great product yields, and a brief reaction time. Additionally, the Ni nanocatalyst could be easily recovered by a simple magnetic separation and recycled at least 8 times without deterioration in catalytic activity.

Keywords:

• MNPs-bis(2-hydroxyethyl)-guanidine-Ni
• Magnetic separation
• Multicomponent reactions
• Pyrano[23-c]pyrazoles
• Highly functionalized piperidines

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Disclosure statement

No potential conflict of interest was reported by the author(s).