A Green Synthesis of Novel Derivatives of Thiazole-5-One Using Magnetic Supported Copper Nanocatalyst (γ-Fe₂O₃@HAp@CPTMS@AT@Cu(ӀI))

Abstract

A highly efficient one-pot three-component protocol was devised for the synthesis of novel derivatives of ((phenylethlidene)hydrazinyl)thiazol-4(5H)one by the reaction of acetophenone derivatives, ethyl chloroacetate and thiosemicarbazide, in ethanol at room temperature in the presence of copper supported hydroxyapatite-encapsulated-γ-Fe₂O₃ (γ-Fe₂O₃@HAp@CPTMS@AT@Cu(ӀI)) as the new magnetically recyclable heterogeneous nanocatalyst. This novel protocol furnished the desired products in excellent yields (88–95%) and short reaction times (20–28 min). The structure and morphology of the synthesized catalyst were characterized by using various techniques such as FT-IR, Fe-SEM, EDX, XRD, TGA-DTA, and VSM.

Graphical Abstract

Keywords:

• γ-Fe₂O₃
• Hydrazinyl-thiazole
• Hydroxyapatite
• One-pot
• Green synthesis
• Nanocatalyst

Acknowledgments

The authors are thankful to the Research Council of University of Guilan for the partial support of this work.

Disclosure statement

No potential conflict of interest was reported by the authors