Electrocatalytic Cascade Selective Approach to 3-Aryl-2'H,3H,4H-Spiro{Furo[2,3-с]Chromene-2,5'-Pyrimidine}-2',4,4',6'(1'H,3'H)Tetraones and Its Automatic Screening Docking Studies

Abstract

The general electrocatalytic cascade approach was found to medicinally relevant spirobarbituric 2,3-dihydro-4H-furo[2,3-c]chromen-4-one scaffold. This new electrocatalytic fast and efficient reaction of benzylidenebarbiturates and 4-hydroxycoumarin in alcohols in the presence of alkali metal halides as mediators in an undivided cell results in the formation of the substituted unsymmetric spirobarbituric 2,3-dihydro-4H-furo[2,3-с]chromen-4-ones in 72–83% yields. This general and efficient approach avoids traditional recrystallization and chromatographic purification stages. According to screening molecular docking data, all synthesized compounds may be prominent for different medical applications, such as control pain, breast cancer therapies, and treatment of obesity, epilepsy, hypertension, cardiovascular disease and diabetes.

Keywords:

• electrocatalysis
• benzylidenebarbiturates
• 4-hydroxycoumarin
• spiro{furo[2,3-c]chromene-2,5'-pyrimidines
• docking studies

Disclosure statement

No potential conflict of interest was reported by the author.

Additional information

Funding

The reported study was funded by RFBR, project number 19-29-08013(Russian Foundation for Basic Research).