Green Synthetic Methods for the Cycloaddition Reactions: A Mini Review

Abstract

Green chemistry, which is an application of a set of principles to decrease or eliminate the use or creation of hazardous chemicals in the design, manufacture, and use of chemical commodities, is one of the most appealing concepts in chemistry for sustainability. Green chemistry has grown in popularity as a consequence of the understanding that environmentally friendly products and methods save mother nature over time. A fundamental key of synthetic chemistry is the creation of ecologically acceptable methods for the synthesis of organic molecules. In many biological applications, new molecules have been synthesized using environmentally friendly processes throughout the past few decades. It is also observed that, in the cycloaddition processes, nature-friendly approaches were focused significantly to avoid environmental pollution caused by toxic solvents and other additives. Hence, we as responsible chemists highly motivated to showcase the green synthetic methods adopted for cycloaddition reactions. In this study, we have reviewed nature-friendly methods utilized for the synthesis of new compounds via Diels–Alder and 1,3-dipolar cycloaddition reactions.

Graphical Abstract

Keywords:

• Green synthesis
• cycloaddition
• Diels–Alder
• 1,3-dipolar cycloaddition

Acknowledgments

The authors acknowledge the Management, Vidyavardhaka College of Engineering, Mysuru for their continuous support.

Disclosure statement

No potential conflict of interest was reported by the author(s).