Future of Ionic Liquids for Chiral Separations in High-Performance Liquid Chromatography and Capillary Electrophoresis

Abstract

The ionic liquids have special features and, hence, called as liquid electrolytes, ionic melts, ionic glasses, fused salts, liquid salts, ionic fluids, designer solvents, green, and future solvents. Achiral and chiral ionic liquids have been used in enantioseparations of a variety of racemates in high-performance liquid chromatography and capillary electrophoresis. Chiral ionic liquids have received a good reputation in high-performance liquid chromatography and capillary electrophoresis because of their astonishing properties. This review discusses the applications of achiral and chiral ionic liquids in enantioseparations in high-performance liquid chromatography and capillary electrophoresis. In addition, the attempts were also made to emphasize the toxicity and future prospective of these ionic liquids. Additionally, the attempts were made to discuss the chiral recognition mechanism.

Keywords:

• Chiral ionic liquids
• chiral recognition mechanism
• chiral separation
• future prospective

Acknowledgments

The authors thank the Deanship of Scientific Research at King Saud University, Riyadh, Saudi Arabia for funding this research (Project No. RGP-150). IA thanks to Deanship of Research, Taibah University, Madinah for financial support.

Disclosure statement

The authors declare that they have no conflict of interests.

Additional information

Funding

The authors thank the Deanship of Scientific Research at King Saud University, Riyadh, Saudi Arabia for funding this research (Project No. RGP-150). IA thanks to Deanship of Research, Taibah University, Madinah for financial support.