The immunology of the macaque placenta: A detailed analysis and critical comparison with the human placenta

Abstract

The cynomolgus monkey is increasingly considered in toxicological research as the most appropriate model for humans due to the species’ close physiological contiguity, including reproductive physiology. Here, literature on the cynomolgus monkey placenta is reviewed in regards to its similarity to the human placenta and particularly for its immunological role, which is not entirely mirrored in humans. Pertinent original data are included in this article. The cynomolgus monkey placenta is evaluated based on three aspects: first, morphological development; second, the spatial and temporal appearance of maternal and fetal immune cells and certain immune cell products of the innate and adaptive immune systems; and third, the expression of relevant immune tolerance-related molecules including the homologs of anti-human leucocyte antigen, indoleamine 2,3-dioxygenase, FAS/FAS-L, annexin II, and progesterone. Parameters relevant to the immunological role of the placenta are evaluated from the immunologically immature stage of gestational day (GD) 50 until more mature stages close to birth. Selected comparisons are drawn with human and other laboratory animal placentas. In conclusion, the cynomolgus monkey placenta has a high degree of morphological and physiological similarity to the human placenta. However, there are differences in the topographical distribution of cell types and immune tolerance-related molecules. Three basic features are recognized: (1) the immunological capacity of the placenta changes throughout the lifetime of the organ; (2) these immunological changes include multiple parameters such as morphological adaptations, cell type involvement, and changes in immune-relevant molecule expression; and (3) the immune systems of two genetically disparate individuals (mother and child) are functionally intertwined at the maternal–fetal interface.

Keywords:

• Cynomolgus monkey
• macaque
• placental morphology
• placental development
• placental immune cells
• immune tolerance
• reproductive toxicology
• reproductive immunology
• placenta
• reproduction

Acknowledgements

The authors gratefully acknowledge Covance Laboratory GmbH, Münster, Germany, for supplying placental tissue, histological materials, and technical processing for this work and Prof. Dr. Thaddeus Golos and Dr. Bryce Wolfe for critical discussion, coreading the manuscript, and giving helpful advices.

Disclosure statement

Both authors report no declarations of interest.