Abstract
Alzheimer’s disease (AD) is the most common form of dementia in elderly people with a high incidence rate and complicated pathogenesis, and causes progressive cognitive deficit and memory impairment. Some natural products and bioactive compounds from natural sources show great potential in the prevention and treatment of AD, such as apple, blueberries, grapes, chili pepper, Monsonia angustifolia, cruciferous vegetables, Herba epimedii, Angelica tenuissima, Embelia ribes, sea cucumber, Cucumaria frondosa, green tea, Puer tea, Amanita caesarea and Inonotus obliquus, via reducing amyloid beta (Aβ) deposition, decreasing Tau hyperphosphorylation, regulating cholinergic system, reducing oxidative stress, inhibiting apoptosis and ameliorating inflammation. This review mainly summarizes the effects of some natural products and their bioactive compounds on AD with the potential molecular mechanisms.
Author’s contribution
Zhijun Yang, Hua-Bin Li and Hui-Lian Zhu conceptualized this study. Zhijun Yang, Dan-Dan Zhou and Si-Yu Huang wrote the original draft of this manuscript. Hua-Bin Li, Hui-Lian Zhu and Ai-Ping Fang contributed in reviewing and editing.
Disclosure statement
The authors declare that there is no conflict of interest regarding the publication of this article.