Role of bioactive peptides derived from food proteins in programmed cell death to treat inflammatory diseases and cancer

Abstract

Bioactive peptides are specific peptide which usually contains 2–20 amino acid residues and actively exerts various functions and biological activities and ultimately affect health. Programmed cell deaths are some styles of cell death discovered in recent years, which is the key to tissue development and balance, eliminating excess, damaged or aging cells. More importantly, programmed cell death is a potential way to treat inflammatory diseases and cancer. In this review, through screening references from 2015 to present, we introduce the effect of bioactive peptides derived from food proteins on inflammatory diseases or cancer through regulating programmed cell deaths, including apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis. And this review also introduces the targets of these bioactive peptides to regulate programmed cell death. The purpose of this review is to help to expand the prospective applications of bioactive peptides in the field of inflammatory disease and cancer to provide some guidance.

Keywords:

• Bioactive peptides
• programmed cell death
• inflammatory diseases
• cancer
• apoptosis
• autophagy
• necroptosis
• pyroptosis
• ferroptosis

Authors’ contribution

Zhao Deng designed and wrote the manuscript. Zhipeng Yang completed the table. Jian Peng designed the manuscript and provided funding, and modified the manuscript.

Disclosure statement

The authors have declared that no conflicts of interest exist.

Additional information

Funding

This research was supported by the National Natural Science Foundation of China (31972578), Hubei province technology innovation special major project (2019ABA081), basic scientific research operating expenses of central universities (2662017PY017), China Agriculture Research System of MOF and MARA (CARS-35).